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Product introduction

双嘧达莫是嘧啶并嘧啶，是2,2',2'',2'''-(嘧啶[5,4-d]嘧啶-2,6-二基二氮基四乙醇)，分别在4和8位被哌啶-1-基取代。作为血管扩张剂，它抑制血栓形成。它具有血管扩张剂、血小板聚集抑制剂、腺苷磷酸二酯酶酶和EC 3.5.4.4(腺苷脱氨酶)抑制剂的活性。它是哌啶类、四醇、嘧啶并嘧啶和三级胺化合物。

Specs ⸢ View details ⸥

Chinese name

双嘧达莫, 3',5'-环磷酸二酯酶抑制剂

English name

2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol

Chinese alias

双嘧达莫 | 二吡待摩 | 双密达莫 | 2,6-双(二乙醇胺)-4,8-二哌啶嘧啶并[5,4-d]嘧啶 | 2,2',2'',2'''-[(4,8-二哌啶基嘧啶并[5,4-d]嘧啶-2,6-二基)二次氮基]四乙醇

English alias

(3E)-3-[[(1S,4aS,8aS)-Decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]methylene]dihydro-5-methoxy-2(3H)3-[(1E)-2-[(1S,4aS,8aS)-Decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]ethenyl]furan; (+)-Coronarin E-furanone; Coronarin D methyl ethe | D

CAS number

58-32-2

molecular formula

C24H40N8O4

molecular weight

504.6

Exact mass

PSA

145

Logp

0.7

Safety

Harmful effect： * 关节痛、背痛、跛行、全身无力、肌痛和僵硬

Toxicity summary：为逆转双嘧达莫的任何并发症和副作用，应准备氨茶碱(50至250毫克静脉推注，30至60秒内给药，且在示踪剂注射后不早于1分钟)以供紧急/紧急使用。这种用法特别在进行药物应激测试期间出现不良反应时使用。

Hepatotoxicity：亚类中的其他药物，抗血小板药物：阿司匹林、坎格雷洛、氯吡格雷、普拉格雷、替格瑞洛、噻氯匹定、沃拉帕沙

Other safety information：化学品评估：IMAP评估 - 乙醇，2,2',2'',2'''-[(4,8-二-1-哌啶基嘧啶并[5,4-d]嘧啶-2,6-二基)四氮基]四-：人类健康I级评估

Hazard categories and classifications： STOT SE 3 (97.3%)

Drug Induced Liver Injury：参考文献：DOI:10.1016/j.drudis.2016.02.015

Effects During Pregnancy and Lactation： ◉ 对哺乳和母乳的影响

Technical Documents

58-32-2 | Dipyridamole, United States Pharmacopeia(USP) Reference Standard.pdf
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