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Product introduction

Hydroxy Dynasore (Dyngo-4a) 是 Dynasore (HY-15304) 结构模拟类似物，是一种改进的，低细胞毒性和通用的 dynamin 抑制剂，针对大脑重组 dynamin I 和重组鼠 dynamin II 的 IC50 值分别为 0.38 μM 和 2.3μM。Hydroxy Dynasore 抑制 dynamin 依赖性转铁蛋白的内吞作用 (endocytosis) 的 IC50 为 5.7 μM。 product description： Hydroxy Dynasore (Dyngo-4a), a structural analog of Dynasore (HY-15304), is an potency improved, low cytotoxicity and non‐specific binding dynamin inhibitor with IC50 values of 0.38 μM and 2.3 μM for brain dynamin I and recombinant rat dynamin II, respectively. Hydroxy Dynasore inhibits dynamin‐dependent endocytosis of transferrin with an IC50 of 5.7 μM in vitro.

Specs ⸢ View details ⸥

Chinese name

Dyngo-4a

English name

Dyngo-4a

Chinese alias

3-羟基-N'-[((2,4,5-三羟基苯基)亚甲基]萘-2-碳酰肼

English alias

CAS number

1256493-34-1

molecular formula

C18H14N2O5

molecular weight

338.31 g/mol

Exact mass

10mM in DMSO

PSA

122.000 Å²

Logp

3.200

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