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DL-丁硫氨酸-SR-亚砜亚胺（BSO）是一种氨基酸类似物，可作为γ-谷氨酰半胱氨酸合成酶的抑制剂。BSO可提高克氏锥虫对抗寄生虫药物（如硝呋莫司或苄硝唑）的敏感性。应用 DL-丁硫氨酸-(S,R)-亚砜亚胺已用于：诱发椋鸟的氧化应激；耗竭出生两天的大鼠幼崽中的脉络膜谷胱甘肽(GSH)；检测其对克氏锥虫(T. cruzi)的γ-谷氨酰半胱氨酸合成酶和 trypanothione（一种锥虫谷胱甘肽）合成酶(TryS)的抑制作用； DL-丁硫氨酸-(S,R)-亚砜亚胺已被用于消耗视网膜神经节细胞 5 (RGC-5) 细胞系中的细胞谷胱甘肽水平。 DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.

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Chinese name

D,L-蛋氨酸-(S,R)-亚磺酰亚胺

English name

D,L-Buthionine-(S,R)-sulfoximine

Chinese alias

2-氨基-4-(S-丁基磺酰亚胺基)丁酸

English alias

CAS number

5072-26-4

molecular formula

C8H18N2O3S

molecular weight

222.31 g/mol

Exact mass

10mM in Water

PSA

113.000 Å²

Logp

-0.600

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