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Product introduction

DBCO-NHCO-PEG4-NH-Boc 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。DBCO-NHCO-PEG4-NH-Boc 可用于合成一系列 PROTAC 分子。DBCO-NHCO-PEG4-NH-Boc 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体活性分子结合物 (ADCs) 的合成。DBCO-NHCO-PEG4-NH-Boc 是一种点击化学试剂。它含有 DBCO 基团，可以和含有 Azide 基团的分子发生环张力 (strain) 促进的炔-叠氮环加成反应 (SPAAC)。 DBCO-NHCO-PEG4-NH-Boc is a PEG derivative with a DBCO group and a Boc-protected amine. The DBCO can undergo copper-free Click Chemistry reactions with azides. The Boc protecting group can be removed under acidic conditions to further react. The hydrophilic PEG linker increases the water solubility of the compound.

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Chinese name

DBCO-NHCO-PEG4-NH-Boc

English name

DBCO-NHCO-PEG4-NH-Boc

Chinese alias

English alias

DBCO-NH-PEG4-NH-Boc

CAS number

1255942-12-1

molecular formula

C34H45N3O8

molecular weight

623.74 g/mol

Exact mass

≥98%

PSA

125.000 Å²

Logp

2.2

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