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Product details

名称

DC_517

分子类型

小分子

英文名称

DC_517

货号

D646685-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

DC_517 is a DNA methyltransferase 1 ( DNMT1 ) inhibitor, with an IC 50 and a K d of 1.7 μM and 0.91 μM, respectively. In Vitro DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC 50 and a K d of 1.7 μM and 0.91 μM, respectively. DC_517 (1.25, 2.5, 5, and 10 μM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC_517 (0, 0.75, 1.5, and 3 μM) also dose-dependently induces apoptotic cell death in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:DNMT1 0.91 μM (Kd) DNMT1 1.7 μM (IC 50 )

生化机理

DC_517 是一种 DNA 甲基转移酶 1（DNMT1）抑制剂，其 IC 50 和 K d 分别为 1.7 μM 和 0.91 μM。

CAS号

500017-70-9

分子式

C33H35N3O2

分子量

505.65 g/mol

Smiles

OC(CNC(C)C)COC(CN1C(C=CC=C2)=C2C3=C1C=CC=C3)CN(C4=CC=CC=C45)C6=C5C=CC=C6

溶解性

DMSO : ≥ 50 mg/mL (98.88 mM)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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