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Product introduction

双叶茶素是一种从 Justicia procumbens 中分离出的芳基萘木脂素，是一种有效的 HIV-1 抑制剂，IC50 为 0.38 μM。双叶茶素还具有抗水泡性口炎病毒 (VSV) 和流感病毒的活性。双叶茶素是 V-ATPase 的抑制剂，IC50 值为 17 nM，可抑制人破骨细胞中的溶酶体酸化。Diphyllin 以 IC50 值为 50 μM 来抑制 NO 产生，并具有抗癌和抗炎活性。产品介绍-英文：应用山荷叶素已用于研究其对鱼类病原体的抗菌和抗生物膜活性。 Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities.

Specs ⸢ View details ⸥

Chinese name

双叶茶素

English name

Diphyllin

Chinese alias

9-(1,3-苯并二恶唑-5-基)-4-羟基-6,7-二甲氧基萘[2,3-c]呋喃-1(3H)-酮 | 双叶茶素 | 二叶草素

English alias

NSC 309691 | 9-(1,3-Benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-naphtho[2,3-c]furan-1(3H)-one

CAS number

22055-22-7

molecular formula

C21H16O7

molecular weight

380.35 g/mol

Exact mass

PSA

83.500 Å²

Logp

3.600

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