Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

DIF-3

分子类型

小分子

英文别名

英文名称

DIF-3

货号

D648796-5mg

包装规格

5mg

浓度

≥98%

储存温度

避光,-80℃储存

运输条件

超低温冰袋运输

产品介绍

DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression. Form:Solid

生化机理

DIF-3 通过激活 GSK-3β 促进细胞周期蛋白 D1 和 c-Myc 的降解，从而降低它们的表达水平。DIF-3 可抑制 DLD-1 细胞中的 Wnt/β-catenin 信号通路相关蛋白。DIF-3可抑制DLD-1细胞中的Wnt/β-catenin信号通路相关蛋白。

CAS号

113411-17-9

分子式

C13H17ClO4

分子量

272.72 g/mol

PubChem编号

3081033

Isomeric SMILES

CCCCCC(=O)C1=C(C(=C(C=C1O)OC)Cl)O

IIUPAC Name

1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one

INCHI

1S/C13H17ClO4/c1-3-4-5-6-8(15)11-9(16)7-10(18-2)12(14)13(11)17/h7,16-17H,3-6H2,1-2H3

InChi Key

JWBMZIJMSBFBIY-UHFFFAOYSA-N

Smiles

CCCCCC(=O)C1=C(C(=C(C=C1O)OC)Cl)O

PubChem CID

3081033

溶解性

DMSO : 100 mg/mL (366.68 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

272.082 Da

单同位素质量Monoisotopic Mass

272.082 Da

拓扑极表面积Topological Polar Surface Area

66.800 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

272

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

RIDADR

NONHforallmodesoftransport

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！