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Product introduction

Duocarmycin DM free base, a DNA minor-groove alkylator , is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity In Vitro The Duocarmycins and CC-1065 are members of a class of DNA minor groove, AT-sequence selective, and adenine-N3 alkylating agents, isolated from Streptomyces sp. that exhibit extremely potent cytotoxicity against the growth of cancer cells grown in culture. Duocarmycin shows cytotoxicity to several human cancer cells, with IC 50 of 22, 13.8, 3.87, 15.4, and 7.31 pM for HT-29, CL1-5, Caski, EJ, and LS174T, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Daunorubicins/Doxorubicins

Specs ⸢ View details ⸥

Chinese name

Duocarmycin DM free base

English name

Duocarmycin DM free base

Chinese alias

多卡米星 DM 游离碱

English alias

[(1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydrobenzo[e]indol-3-yl]-[5-[2-(dimethylamino)ethoxy]-1H-indol-2-yl]methanone

CAS number

1116745-06-2

molecular formula

C26H26ClN3O3

molecular weight

463.96 g/mol

Exact mass

PSA

68.800 Å²

Logp

4.7

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