D4-abiraterone

小分子

D4-阿比特龙

GYJZZAJJENTSTP-NHFPKVKZSA-N | .DELTA.4-ABIRATERONE | Androsta-4,16-dien-3-one, 17-(3-pyridinyl)- | CAS-2140-46-7 | BDBM50216168 | CB 7627 | UNII-Z2L6XS2R7H | U7P | CB7627 | CB-7627 | (8alpha)-17-(pyridin-3-yl)androsta-4,16-dien-3-one | Q30647364 | 17-(3-P

D4-abiraterone

D649990-5mg

5mg

≥99%

2-8°C储存

冰袋运输

D4-abiraterone is a major metabolite of abiraterone. D4-abiraterone is an inhibitor of CYP17A1 , 3b-hydroxysteroid dehydrogenase ( 3βHSD ) and steroid-5a-reductase ( SRD5A ) and also an antagonist of androgen receptor . In Vitro D4-abiraterone (D4A ) (10 mM) nearly completely blocks conversion from D4-androstenedione (AD) to 5α-androstanedione and other 5α-reduced androgens. The affinity of D4-abiraterone for mutant (expressed in LNCaP, half-maximum inhibitory concentration (IC 50 =5.3 nM)) and wild type (expressed in LAPC4, IC 50 =7.9 nM) androgen receptor (AR) is greater than that of abiraterone (Abi) (IC 50 =418 and >500 nM, respectively). Compare with Abi, D4-abiraterone clearly better suppresses PSA, TMPRSS2 and FKBP5 expression in LNCAP, LAPC4 and C4-2 cell lines. D4-abiraterone also inhibits AR target gene expression in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo D4-abiraterone (D4A) is tenfold more potent than abiraterone (Abi) in blocking conversion from dehydroepiandrosterone (DHEA) by 3β-hydroxysteroid dehydrogenase (3βHSD) to D4-androstenedione (AD) in LNCaP and VCaP xenografts. 0.1 μM D4-abiraterone is equivalent to 1 μM Abi for blocking AD accumulation at 48 h in both LNCaP and VCaP xenografts. Progression is significantly delayed in the D4-abiraterone group compare with the Abi acetate group (P=0.011). D4-abiraterone treatment increases progression-free survival compare with Abi acetate . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CYP17A1, 3βHSD, SRD5A, androgen receptor

D4-阿比特龙是阿比特龙的主要代谢产物。D4-阿比特龙是 CYP17A1、3b-羟基类固醇脱氢酶（3βHSD）和类固醇-5a-还原酶（SRD5A）的抑制剂，也是雄激素受体的拮抗剂。

154229-21-7

C24H29NO

347.49 g/mol

196941

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CN=CC=C5)C

(8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-one

1S/C24H29NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-4,7,13-15,19,21-22H,5-6,8-12H2,1-2H3/t19-,21-,22-,23-,24+/m0/s1

GYJZZAJJENTSTP-NHFPKVKZSA-N

CC12CCC(=O)C=C1CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C

196941

DMSO : 50 mg/mL (143.89 mM; Need ultrasonic)

0

2

1

347.225 Da

347.225 Da

30.000 Ų

26

0

676

0

1

4.6

NONHforallmodesoftransport