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Product details

名称

Diaplasinin

分子类型

小分子

别名

抗凝素

英文别名

PAI-749

英文名称

Diaplasinin

货号

D650860-5mg

包装规格

5mg

级别

Moligand™

浓度

≥98%

储存温度

避光,-20°C储存

运输条件

超低温冰袋运输

敏感性

对光线敏感，对湿度敏感

产品介绍

Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 ( PAI-1 ) inhibitor with IC 50 of 295 nm. Antithrombotic efficacy. In Vitro PAI-749 is a potent and selective synthetic antagonist of plasminogen activator inhibitor 1 (PAI-1) that preserved tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) activities in the presence of PAI-1 (IC 50 values, 157 and 87 nM, respectively). PAI-749 quenches the fluorescence (Fl) of fluorophore-tagged PAI-1 (PAI-NBD119) with the apparent K d of 254 nM) and the IC 50 of 140 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

Diaplasinin（PAI-749）是一种纤溶酶原激活物抑制剂-1（PAI-1）抑制剂，IC50 为 295u2003nm。抗血栓功效。

CAS号

481631-45-2

分子式

C32H31N5O

分子量

501.62 g/mol

PubChem编号

6450820

Isomeric SMILES

CCCCCC1=C(N(C2=CC=CC=C21)CC3=CC=CC=C3)C4=CC5=C(C=C4)C=C(C=C5)OCC6=NNN=N6

Smiles

CCCCCC1=C(N(C2=CC=CC=C21)CC3=CC=CC=C3)C4=CC5=C(C=C4)C=C(C=C5)OCC6=NNN=N6

PubChem CID

6450820

溶解性

DMSO : 125 mg/mL (249.19 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

501.253 Da

单同位素质量Monoisotopic Mass

501.253 Da

拓扑极表面积Topological Polar Surface Area

68.600 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

716.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

8.000

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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