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Product details

名称

DM4-SMe

英文名称

DM4-SMe

货号

D651288-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs) , which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC 50 of 0.026 nM Form:Solid IC50& Target:Maytansinoids

生化机理

DM4-SMe是抗体-麦他辛共轭物（AMCs）的代谢产物，是一种微管蛋白抑制剂，也是抗体-药物共轭物（ADCs）的细胞毒性分子，可通过二硫键或稳定的硫醚键与抗体连接。DM4-SMe 可抑制 KB

CAS号

796073-68-2

分子式

C39H56ClN3O10S2

分子量

826.46 g/mol

PubChem编号

11542407

Isomeric SMILES

C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)SSC)C)\C)OC)(NC(=O)O2)O

IIUPAC Name

[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl-[4-methyl-4-(methyldisulfanyl)pentanoyl]amino]propanoate

INCHI

1S/C39H56ClN3O10S2/c1-22-13-12-14-29(50-10)39(48)21-28(51-36(47)41-39)23(2)34-38(6,53-34)30(20-32(45)43(8)26-18-25(17-22)19-27(49-9)33(26)40)52-35(46)24(3)42(7)31(44)15-16-37(4,5)55-54-11/h12-14,18-19,23-24,28-30,34,48H,15-17,20-21H2,1-11H3,(H,41,47)/b14-12+,22-13+/t23-,24+,28+,29-,30+,34+,38+,39+/m1/s1

InChi Key

LTLNAIFGVAUBEJ-SIDGEOBYSA-N

Smiles

CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)CCC(C)(C)SSC)C)C)OC)(NC(=O)O2)O

PubChem CID

11542407

溶解性

DMSO : 100 mg/mL (121.00 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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