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Product details

名称

Depulfavirine

分子类型

小分子

别名

德普法韦林

英文名称

Depulfavirine

货号

D651659-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC 50 of 1.1 nM and retained activity (IC 50 Form:Solid

生化机理

RO-0335是一种新型强效二苯醚类非核苷逆转录酶抑制剂（NNRTI）。RO-0335 对 Wt HIV-1 的抑制作用 IC 50 为 1.1 nM，对大量耐 NNRTI 的临床分离株中的 92% 保持活性（IC 50 < 100 nM）。

CAS号

867365-76-2

分子式

C21H13BrCl2FN3O4S

分子量

573.22 g/mol

PubChem编号

11599486

Isomeric SMILES

C1=CC(=C(C=C1S(=O)(=O)N)Cl)NC(=O)CC2=C(C(=C(C=C2)Br)OC3=CC(=CC(=C3)C#N)Cl)F

Smiles

C1=CC(=C(C=C1S(=O)(=O)N)Cl)NC(=O)CC2=C(C(=C(C=C2)Br)OC3=CC(=CC(=C3)C#N)Cl)F

PubChem CID

11599486

溶解性

DMSO : 250 mg/mL (436.13 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

570.917 Da

单同位素质量Monoisotopic Mass

570.917 Da

拓扑极表面积Topological Polar Surface Area

131.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

854

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.6

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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