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Product details

名称

DCVC

分子类型

小分子

英文名称

DCVC

货号

D651785-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8 , and TNF-α release from tissue cultures. In Vitro Extraplacental membranes are cultured for 4, 8, and 24h with the trichloroethylene (TCE) metabolite S-(1,2-dichlorovinyl)-l-cysteine (DCVC) in the absence or presence of lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to simulate infection. In addition, membranes were cocultured with DCVC and Group B Streptococcus (GBS). DCVC (5-50μM) significantly inhibited LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4h. DCVC inhibits pathogen-stimulated cytokine (IL-1β, IL-8, and TNF-α) release in a concentration-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

DCVC（S-[(1E)-1,2-二氯乙烯基]--L-半胱氨酸）是三氯乙烯（TCE）的一种生物活性代谢物。DCVC 可抑制组织培养物在病原体刺激下释放的促炎细胞因子 IL-1β、IL-8 和 TNF-α。

CAS号

13419-46-0

分子式

C5H7Cl2NO2S

分子量

216.09 g/mol

PubChem编号

16738704

Isomeric SMILES

C([C@@H](C(=O)O)N)S/C(=C\Cl)/Cl

Smiles

C([C@@H](C(=O)O)N)S/C(=C\Cl)/Cl

PubChem CID

16738704

溶解性

DMSO : 2.5 mg/mL (11.57 mM; Need ultrasonic) H2O : 1.034 mg/mL (4.79 mM; Need ultrasonic and warming)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

214.957 Da

单同位素质量Monoisotopic Mass

214.957 Da

拓扑极表面积Topological Polar Surface Area

88.600 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

174

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

-1.1

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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