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名称

DG051

英文名称

DG051

货号

D651905-5mg

包装规格

5mg

浓度

≥99%

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

DG051 is a potent leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC 50 =47 nM. In Vitro DG051 is a potent inhibitor of LTA4H aminopeptidase activity against L-alanine p-nitroanilide (IC 50 =72 nM). DG051 inhibits human whole blood (HWB) with IC 50 of 37 nM. As applied within the context of LTA4H inhibitor design, the chemistry team is able to design a potent DG051(K d =26 nM) with high aqueous solubility (>30 mg/mL) and high oral bioavailability (>80% across species) that is currently undergoing clinical evaluation for the treatment of myocardial infarction and strokeDG-051 is a first-in-class small molecule inhibitor of leukotriene A4 hydrolase (LTA4H), currently in Phase II clinical development for the prevention of heart attack. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 47 nM (LTA4H)

生化机理

DG051 是一种强效的白三烯 A4 水合酶抑制剂，在酶测定中可抑制白三烯 B4 的生物合成，IC 50 =47 nM。

CAS号

929915-58-2

分子式

C21H25Cl2NO4

分子量

426.33 g/mol

PubChem编号

44818987

Isomeric SMILES

C1C[C@H](N(C1)CCCC(=O)O)COC2=CC=C(C=C2)OC3=CC=C(C=C3)Cl.Cl

Smiles

C1C[C@H](N(C1)CCCC(=O)O)COC2=CC=C(C=C2)OC3=CC=C(C=C3)Cl.Cl

PubChem CID

44818987

溶解性

DMSO : ≥ 325 mg/mL (762.32 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

425.116 Da

单同位素质量Monoisotopic Mass

425.116 Da

拓扑极表面积Topological Polar Surface Area

59.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

447.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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