DuP 734

小分子

DuP 734

D654870-1ml

1ml

10mM in DMSO

充氩,-80℃储存

超低温冰袋运输

DuP 734 is a sigma receptor antagonist. DuP 734 is a selective and potent sigma and 5-HT2 receptor ligand with weak affinity for D2 receptors. DuP 734 may have antipsychotic activity without the liability of motor side effects typical of neuroleptics In Vivo DuP 734 potently blocks mescaline-induced scratching (ED 50 =0.35 mg/kg, p.o.) and aggressive activity (ED 50 =1.9 mg/kg, p.o.) and is relatively much weaker as an apomorphine antagonist (ED 50 =12 mg/kg, p.o.) . Administration of DuP 734 potently antagonizes the binding of [ 3 H]DuP 734 and [ 3 H](+)-SKF 10,047 to brain sigma receptors in vivo with ID 50 values of 0.02 and 0.07 mg/kg (0.07 and 0.25μmol/kg), respectively. Following intravenous dosing, the disposition of DuP 734 in mice, rats, beagle dogs and cynomolgus monkeys is characterized by high total body systemic plasma clearance (46 to 87 mL/min/kg) and large steady-state volume of distribution (3.6 to 6.8 L/kg). The terminal elimination half-life ranged from 50 to 83 min. The gastrointestinal absorption from an aqueous solution is very rapid in mice and rats with peak DuP 734 plasma concentrations attain within 5 and 20 min following administration, respectively. The peak plasma concentrations in dogs and monkeys are attained within 45 and 130 min, respectively. The absolute bioavailability in mice ranges from 29 to 46% at doses of 3.1 to 30.1 mg/kg. The bioavailability increases from 4 to 10% and from 14 to 72% when doses are increased from 12.5 to 50 mg/kg and 1 to 3 mg/kg of DuP 734 in rats and dogs, respectively. The bioavailability in monkeys is 30.5% at 9.3 mg/kg DuP 734 dose. The dose dependent pharmacokinetics of DuP 734 is observed within narrow dose ranges in all animal species investigated. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Sigma receptor,5-HT2 receptor,D2 receptor

DuP 734 是一种西格玛受体拮抗剂。DuP 734 是一种选择性强的 sigma 和 5-HT2 受体配体，对 D2 受体的亲和力较弱。DuP 734 可能具有抗精神病活性，但不会产生典型的神经抑制剂的运动副作用。

135135-87-4(DMSO)

C17H23BrFNO

356.27 g/mol

C1CC1CN2CCC(CC2)CC(=O)C3=CC=C(C=C3)F.Br