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Product details

名称

DIF-3

英文名称

DIF-3

货号

D655574-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

避光,-80℃储存

运输条件

超低温冰袋运输

产品介绍

DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression.

生化机理

DIF-3 通过激活 GSK-3β 促进细胞周期蛋白 D1 和 c-Myc 的降解，从而降低它们的表达水平。DIF-3 可抑制 DLD-1 细胞中的 Wnt/β-catenin 信号通路相关蛋白。DIF-3可抑制DLD-1细胞中的Wnt/β-catenin信号通路相关蛋白。

CAS号

113411-17-9(DMSO)

分子式

C13H17ClO4

分子量

272.72 g/mol

Smiles

CCCCCC(=O)C1=C(C(=C(C=C1O)OC)Cl)O

CMGC

包含CDK，MAPK，GSK3，CLK家族

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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