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Product details

名称

DMP 777

分子类型

小分子

英文名称

DMP 777

货号

D655916-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

充氩,-80℃储存

运输条件

超低温冰袋运输

产品介绍

DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor. In Vivo DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministered\nwith omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats thatreceive DMP-777 alone . After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP-777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Human leukocyte elastase (HLE)

生化机理

DMP 777 是一种强效、选择性和口服活性的人类白细胞弹性蛋白酶（HLE）抑制剂。

CAS号

157341-41-8(DMSO)

分子式

C31H40N4O6

分子量

564.69 g/mol

Smiles

CCCC(C1=CC2=C(C=C1)OCO2)NC(=O)N3C(C(C3=O)(CC)CC)OC4=CC=C(C=C4)C(=O)N5CCN(CC5)C

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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