DAA-1106

小分子

DAA-1106

D656097-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

DAA1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), as a potent and selective agonist at the peripheral benzodiazepine receptor.Target:PBRin vitro: DAA1106 binding to PBR was significantly increased in widespread areas in MCI subjects when compared to healthy controls.DAA-1106 is a drug which acts as a potent and selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO, but with no affinity at the GABAA receptor.in vivo: DAA-1106 has anxiolytic effects in animal studies. DAA-1106 has a sub-nanomolar binding affinity (Ki) of 0.28nM, and has been used extensively in its 3H or 11C radiolabelled form to map TSPO in the body and brain, which has proved especially helpful in monitoring the progress of neurodegenerative diseases such as Alzheimer's disease.

DAA1106是外周苯并二氮杂卓受体（PBR）的强效选择性配体，是外周苯并二氮杂卓受体的强效选择性激动剂：DAA1106与苯并二氮杂卓受体（PBR）的结合在广泛的体外实验中明显增加。

220551-92-8(DMSO)

C23H22FNO4

395.42 g/mol

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