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Product details

名称

DMU2105

英文名称

DMU2105

货号

D656801-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

DMU2105 is a potent and specific CYP1B1 inhibitor, with IC 50 s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. In Vitro DMU2105 (Compound 7k) shows 74 and 120-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2105 however, the EC 50 goes down to 1 μM indicating that the cells have suffered from toxicity which may have been mediated by CYP1B1 inhibition. Un-transfected cells (HEK293: pcDNA3.1), when treated with cisplatin and DMU2105 (10×IC 50 ) do not show any perceptible decrease of cisplatin EC 50 (8.5 μM ± 0.9). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:CYP1B1 10 nM (IC 50 ) CYP1A1 742 nM (IC 50 )

生化机理

DMU2105 是一种强效的特异性 CYP1B1 抑制剂，对 CYP1B1 和 CYP1A1 的 IC 50 s 分别为 10 nM 和 742 nM。

CAS号

1821143-79-6(DMSO)

分子式

C18H13NO

分子量

259.30 g/mol

Smiles

C1=CC=C2C=C(C=CC2=C1)C=CC(=O)C3=CN=CC=C3

Reaxy-Rn

35887540

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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