Dabigatran ethyl ester hydrochloride

达比加群乙酯盐酸盐

Dabigatran ethyl ester hydrochloride

D656814-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase ( NQO2 ) with an IC 50 value of 0.8 μM and a thrombin inhibitor. In Vitro The K i of dabigatran (ethyl ester hydrochloride) toward NQO2 is 0.9 μM and the IC 50 is 0.8 μM. The ethyl ester group of dabigatran (ethyl ester hydrochloride) significantly extends the interaction surface especially with hydrophobic amino acids such as Ile 128 and Met 154. Dabigatran ethyl ester has higher affinity than Dabigatran to both thrombin and NQO2. Dabigatran is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Dabigatran (K i =4.5 nM) could bind to human thrombin selectively, and reversibly to realize a strong and long-lasting anticoagulant effect. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 0.8 μM (NQO2)

达比加群乙酯盐酸盐是一种强效的核糖酸二氢烟酰胺脱氢酶（NQO2）抑制剂，IC50 值为 0.8 μM，也是一种凝血酶抑制剂。

211914-50-0(DMSO)

C27H30ClN7O3

536.04 g/mol

CCOC(=O)CCN(C1=CC=CC=N1)C(=O)C2=CC3=C(C=C2)N(C(=N3)CNC4=CC=C(C=C4)C(=N)N)C.Cl