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Product introduction

DS-7423 is a dual PI3K and mTOR inhibitor, with IC 50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR , respectively. DS-7423 possesses anti-tumor activity. In Vitro DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells. DS-7423 also inhibits other isoforms of class I PI3K (IC 50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

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Chinese name

DS-7423

English name

DS-7423

Chinese alias

English alias

CAS number

1222104-37-1

molecular formula

C22H27F3N10O2

molecular weight

520.51 g/mol

Exact mass

≥99%

PSA

Logp

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