DL-Buthionine-(S,R)-sulfoximine hydrochloride

DL-丁硫氨酸-(S,R)-亚砜亚胺盐酸盐

DL-Buthionine-(S,R)-sulfoximine hydrochloride

D659124-50mg

50mg

≥98%

2-8°C储存,避光,干燥

冰袋运输

DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis . Appearance:Solid IC50& Target:Glutamylcysteine synthetase In Vitro:Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine. MCE has no In Vivo:Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tum Biological Activity:DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis .

C8H19ClN2O3S

258.77 g/mol

OC(C(N)CCS(CCCC)(=N)=O)=O.[H]Cl

H2O : ≥ 140 mg/mL (541.02 mM) DMSO : ≥ 125 mg/mL (483.05 mM) Ethanol : 25 mg/mL (96.61 mM; Need ultrasonic)