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Product details

名称

D-Cl-amidine hydrochloride

别名

D-Cl-脒盐酸盐

英文名称

D-Cl-amidine hydrochloride

货号

D659324-5mg

包装规格

5mg

浓度

≥99%

储存温度

避光,-20°C储存,充氩

运输条件

超低温冰袋运输

产品介绍

D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity. Appearance:Solid In Vitro:D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells. D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis. MCE has not independently conf In Vivo:D-Cl-amidine, administered by iv at a dose of 2.5mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ∼10 nM at 4 h when administered by ip Biological Activity:D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity.

分子式

C14H20Cl2N4O2

分子量

347.24 g/mol

Smiles

O=C(N[C@@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1.[H]Cl

溶解性

DMSO : 80 mg/mL (230.39 mM; ultrasonic and warming and heat to 60°C) H2O : 16.67 mg/mL (48.01 mM; ultrasonic and warming and heat to 60°C)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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