- Hepatotoxicity： Likelihood score: E (unlikely cause of clinically apparent liver injury).
- Adverse Effects： Use docusate with caution when administering it with mineral oil, as there might be increased absorption of the mineral oil, potentially leading to systemic lipid granulomas.
- Hazards Summary： No evidence of teratogenicity in rats or humans; One case report of hypomagnesemia associated with maternal excessive/chronic use of laxatives by the mother; [REPROTOX] See Docusate sodium.
- Toxicity Summary： Docusate is metabolized in the liver, where it undergoes significant first-pass metabolism, forming both active and inactive metabolites. Although docusate undergoes hepatic metabolism and has high plasma protein binding, there have been no reports of clinically apparent hepatoxicity.
- Regulatory Information： The Australian Inventory of Industrial Chemicals: Chemical: Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester
- Drug Induced Liver Injury： References: DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： Relevant published information was not found as of the revision date.
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Research chemical 1mg
Research chemical 1mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1mg.
1mg
