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Product introduction
多潘立酮是1-[3-(哌啶-1-基)丙基]-1,3-二氢-2H-苯并咪唑-2-酮,其中哌啶环的4位被5-氯-1,3-二氢-2H-苯并咪唑-2-酮-1-基取代。作为一种多巴胺拮抗剂,它用作止吐药,短期治疗恶心和呕吐,并控制用于帕金森病管理的多巴胺类药物的胃肠道影响。游离碱用于口服混悬液,而马来酸盐用于片剂制剂。它具有多巴胺拮抗剂和止吐药的作用。它是苯并咪唑类和杂芳基哌啶的成员。
Chinese name
多潘立酮, 多巴胺 D2 受体拮抗剂
English name
6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
Chinese alias
多潘立酮 | 5-氯-1-[1-[3-(2-氧代-1-苯并咪唑)丙基]4-哌啶基]苯并咪唑-2-酮
English alias
DOMPERIDONE [INN] | HMS3656M21 | KBioGR_000354 | MLS000859942 | SCHEMBL43729 | 5587267Z69 | HMS3261E16 | NSC 299589 | DTXCID9025116 | NSC299589 | NSC-299589 | HMS2089C14 | NCIStruc2_001819 | Spectrum4_000087 | 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2
CAS number
57808-66-9
molecular formula
C22H24ClN5O2
molecular weight
425.9
Exact mass
-
PSA
67.9
Logp
3.9
Safety
  • Other safety information: 化学品评估:IMAP评估 - 2H-苯并咪唑-2-酮,5-氯-1-[1-[3-(2,3-二氢-2-氧代-1H-苯并咪唑-1-基)丙基]-4-哌啶基]-1,3-二氢-:环境I级评估
  • Hazard categories and classifications: 代表性化合物2 (89.8%)
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: 一名50岁的跨性别女性希望哺乳其伴侣预期的婴儿。她被给予多潘立酮,剂量从每天30 mg逐渐增加到80 mg,同时给予雌二醇和孕激素以刺激泌乳。患者能够产生少量乳汁,并能够直接哺乳婴儿。
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Research chemical CAS 57808-66-9 1ml

Macklin Research chemical CAS 57808-66-9 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:D689203-1ml
Product model:1ml
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Lead Time:30days
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