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Product introduction
地美溴铵是2,13-二氮杂十四烷的N,N'-双[3-(二氨基)苯基氨基甲酸酯]的甲溴化物盐。它是乙酰胆碱酯酶和假性胆碱酯酶的抑制剂,作用持久。用于治疗慢性开角型青光眼:在眼睛中,它引起虹膜括约肌和睫状肌收缩,促进房水流出,从而降低眼内压。它具有EC 3.1.1.8(胆碱酯酶)抑制剂和EC 3.1.1.7(乙酰胆碱酯酶)抑制剂的作用。它是溴化物盐、氨基甲酸酯酯和季铵盐。它含有地美卡铵。
Chinese name
地美溴铵
English name
trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium dibromide
Chinese alias
-
English alias
3,3'-(1,10-Decanediylbis((methylimino)carbonyloxy))bis(N,N,N-trimethyl-benzenaminium)) dibromide
CAS number
56-94-0
molecular formula
C32H52Br2N4O4
molecular weight
716.6
Exact mass
-
PSA
59.1
Logp
6.6
Safety
  • interaction: ...地美卡铵产生的抑制是"可逆的"。药物的局部作用可被阿托品和普拉立姆(Protopam)拮抗。地美卡铵的作用不被毒扁豆碱的预先滴注所抑制。/地美卡铵/
  • Hazard categories and classifications: 急性毒性2(100%)
  • Non-human toxic extract: 鸟类胚胎中的神经活性化合物与脊椎畸形。暴露于地美溴铵(1.5毫克)的鹌鹑胚胎在3天后出现脊椎融合和颈部畸形。讨论了畸形的机制。
  • Antidote and first aid: 据报道,虹膜囊肿的出现与给药频率有关,停药后这些囊肿会消失。应定期检查患者是否出现虹膜囊肿,如果出现,应至少暂时停止治疗。
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
Related
upstream information
Manufacturing method:
乙醇 (CID:702);丙酮 (CID:180);甲基溴 (CID:6323)
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Demecarium Bromide 10mM in DMSO 1ml

Demecarium Bromide 10mM in DMSO 1ml Macklin 56-94-0, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number:D795194-1ml
Product model:1ml
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Lead Time:30days
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