ACSS2 inhibitor 是有效的、特异性的乙酰辅酶A合成酶2 (ACSS2)抑制剂。ACSS2 inhibitor 还可抑制呼吸道合胞体病毒(RSV)。 A cell-permeable quinoxaline based compound that acts as a potent, reversible inhibitor of acetyl CoA synthetase (ACSS2; IC50 ~ 600 nM in a luciferase based assay). Exhibits selectivity over ACSF2 and ACSL5 acyl-CoA synthetases. Efficiently blocks the uptake of 14C tracer carbons from acetate into lipids (IC50 = 6.8 µM) and for histone acetylation (IC50 = 5.5 µM) in HepG2 cells. A cell-permeable quinoxaline based compound that acts as a potent, reversible inhibitor of acetyl CoA synthetase (ACSS2; IC50 ~ 600 nM in a luciferase based assay). Exhibits selectivity over ACSF2 and ACSL5 acyl-CoA synthetases. Efficiently blocks the uptake of 14C tracer carbons from acetate into lipids (IC50 = 6.8 µM) and for histone acetylation (IC50 = 5.5 µM) in HepG2 cells. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.