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Product introduction

Dovitinib (TKI-258, CHIR-258)是一种多靶点的RTK抑制剂，对III型(FLT3/c-Kit)作用最强，IC50为1 nM/2 nM，同时也作用于IV类(FGFR1/3)和V类(VEGFR1-4) RTKs，IC50为8-13 nM，但对InsR， EGFR， c-Met， EphA2， Tie2， IGF-1R和HER2作用较弱。The free base form of an FGFR inhibitor Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2. The free base form of an FGFR inhibitor

Specs ⸢ View details ⸥

Chinese name

多维替尼 (TKI-258, CHIR-258), 集落刺激因子 1 受体抑制剂

English name

Dovitinib (TKI-258, CHIR-258)

Chinese alias

English alias

CHIR-258 | C75053 | D77370 | BDBM153731 | GFKI-258 | MFCD10565680 | NCGC00249685-11 | TK-258 | AC-32059 | B2693-091881 | Dovitinib | Q27163255 | SCHEMBL32934 | 1447274-99-8 | 4-AMINO-5-FLUORO-3-[ 5- (4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2

CAS number

405169-16-6

molecular formula

C21H21FN6O

molecular weight

392.43 g/mol

Exact mass

PSA

90.300 Å²

Logp

1.6

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Dovitinib (TKI-258, CHIR-258) 10mM in DMSO 1ml

Name: Dovitinib (TKI-258, CHIR-258) 10mM in DMSO 1ml
Brand: 麦克林
SKU: D797211-1ml

Dovitinib (TKI-258, CHIR-258) 10mM in DMSO 1ml Macklin 405169-16-6, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number：D797211-1ml

Product model：1ml

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Lead Time：30days

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Dovitinib (TKI-258, CHIR-258) 10mM in DMSO 1ml

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