Reactant for preparation of: . HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p75 . Inhibitors of Gli1-mediated transcription in the Hedgehog pathway . SCIO-469-like compounds for the inhibition of p38 MAP kinase . 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles as protein kinase c theta (PKC θ) inhibitors . Non-covalent thrombin inhibitors Reactant for preparation of: . HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p75 . Inhibitors of Gli1-mediated transcription in the Hedgehog pathway . SCIO-469-like compounds for the inhibition of p38 MAP kinase . 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles as protein kinase c theta (PKC θ) inhibitors . Non-covalent thrombin inhibitors