Dolastatin 15是dolastatin家族的成员。Dolastatins是从海兔中分离出的海洋天然产物，具有与Dolastin 10相关的结构。Dolastatin15是一种抗肿瘤假肽，可抑制微管蛋白依赖性GTP水解为微管蛋白，但已证明与RZX / MAY结合地区。该化合物通过与微管蛋白的长春蔓域结合而充当弱微管蛋白抑制剂，并通过几种恶性细胞类型中的Bcl-2磷酸化诱导凋亡。鼠和癌细胞系以及造血祖细胞增殖的有效抑制剂。当添加到白血病培养物中时，Dolastin 15会抑制免疫球蛋白的产生和细胞增 Dolastatin 15 is a member of the dolastatin family. Dolastatins are marine natural products isolated from the sea hare|Dolabella auricularia|with a structure related to Dolastin 10. Dolastatin 15 is an anti-neoplastic pseudopeptide that inhibits Tubulin-dependent GTP hydrolysis to Tubulin but has been shown to bind to the RZX/MAY region. The compound acts as a weak Tubulin inhibitor by binding to the vinca domain of tubulin and induces apoptosis through Bcl-2 phosphorylation in several malignant cell types. Potent inhibitor of the proliferation of murine and cancer cell lines as well as that of hematopoietic progenitor cells. When added to leukemia cultures Dolastin 15 inhibited both immunoglobulin production and cell proliferation.