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Product introduction
物理描述 | 1-苯基-3-甲基-5-吡唑酮呈现为白色至淡白色粉末或晶体。(NTP, 1992)
Chinese name
3-甲基-1-苯基-2-吡唑啉-5-酮
English name
5-methyl-2-phenyl-4H-pyrazol-3-one
Chinese alias
1-苯基-3-甲基-5-吡唑酮;吡唑啉酮;1,3,5-吡唑酮;2,4-二氢-5-甲基-2-苯基-3<i>H</i>-吡唑-3-酮
English alias
PMP | N-DESMETHYLANTIPYRINE | AE-641/00371017 | Edaravone [USAN:INN] | NSC-26139 | CI Developer 1 | PHENAZONE IMPURITY A (EP IMPURITY) | 5-Pyrazolone, 3-methyl-1-phenyl- | KBioSS_000747 | SR-01000000135 | 1-Phenyl-3-methyl-5-pyrazolone | MCI-186 | 3-methy
CAS number
89-25-8
molecular formula
C10H10N2O
molecular weight
174.20
Exact mass
-
PSA
32.7
Logp
1.3
Safety
  • Health hazard: 急/慢性危害:该化合物可能引起皮肤和眼睛刺激。经口摄入具有中等毒性。加热分解时会产生有毒烟雾。(NTP, 1992)
  • Hazard summary: 紧急处理:刺激物;皮肤、眼睛和粘膜刺激物;[CAMEO] 对兔子的皮肤和眼睛造成无至轻度刺激;对豚鼠皮肤无致敏性;[IUCLID] 实验动物中未观察到致畸性,但在高剂量下观察到出生体重降低和胎儿丢失;[REPROTOX] 未发现对小鼠或大鼠有致癌性证据;[NTP] 轻度眼睛刺激剂;在狗的静脉研究中导致肝脏和脾脏变化;[RTECS]
  • reactive group: 烃类,芳香族
  • First aid measures: 食入:不要催吐。如果受害者意识清醒且没有抽搐,给予1-2杯水稀释化学物质,并立即呼叫医院或中毒控制中心。如果医生建议,准备将受害者送往医院。如果受害者抽搐或昏迷,不要经口给予任何东西,确保受害者的气道通畅,让受害者侧卧,头部低于身体。不要催吐。立即将受害者送往医院。(NTP, 1992)
  • Toxicity summary: 化妆品成分审查发现:在当前使用实践和浓度下安全。成分、浓度和使用信息可在https://cir-reports.cir-safety.org上可发现的文档中获得
  • Regulatory information: 新西兰化学品清单状态:3H-吡唑-3-酮,2,4-二氢-5-甲基-2-苯基-:没有单独批准,但可在适当的团体标准下使用
  • fire hazard: 该化学品的闪点数据不可用。它可能是可燃的。(NTP, 1992)
  • fire fighting: 涉及此材料的火灾可以用干化学灭火器、二氧化碳或哈龙灭火器控制。(NTP, 1992)
  • Hepatotoxicity: 可能性评分:E(不太可能引起明显的肝损伤)。
  • Special Reports: DHEW/NCI;1-苯基-3-甲基-5-吡唑酮致癌性生物测定(1978) 技术报告系列第141号 DHEW出版物号(NIH)78-1396
  • reactivity profile: 胺是化学碱。它们中和酸形成盐和水。这些酸碱反应是放热的。每摩尔胺在中和过程中释放的热量 largely independent of the strength of the amine as a base. 胺可能与异氰酸酯、卤代有机物、过氧化物、酚类(酸性)、环氧乙烷、酸酐和酰卤不相容。胺与强还原剂(如氢化物)结合会产生易燃的氢气。
  • ecotoxicity value: 美国农业部APHIS化学效应:collection=usda_chemeffect&query_type=synonym&query='^89-25-8$'
  • Other safety information: 化学品评估:IMAP评估 - 3H-吡唑-3-酮,2,4-二氢-5-甲基-2-苯基-:人类健康II级评估
  • Air and water reaction: 不溶于水。
  • Hazard categories and classifications: 皮肤致敏 - 类别 1
  • Non-fire leakage response: 储存注意事项:您应将此材料存放在冰箱中。(NTP, 1992)
  • Personal protective equipment (PPE): 推荐呼吸器:在称量和稀释纯测试化学品时,佩戴NIOSH批准的半面罩呼吸器,配备有机蒸气/酸性气体 cartridges(专门用于有机蒸气、HCl、酸性气体和SO2)和粉尘/雾过滤器。(NTP,1992)
  • Protective Action Standards (PAC): PAC-3:380 [mg/m3]
  • Carcinogen Classification: 摘要:在本生物测定条件下,没有发现1-苯基-3-甲基-5-吡唑酮对Fischer 344大鼠或B6C3F1小鼠有致癌性证据。
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
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Manufacturing method:
苯肼(CID:7516);乙酰乙酸乙酯(CID:8868)
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Research chemical 1ml

Research chemical 1ml; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1ml.

item number:E408892-1ml
Product model:1ml
level: 1ml
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