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名称

EP1013

英文名称

EP1013

货号

E647027-5mg

包装规格

5mg

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

EP1013 (F1013) is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes In Vivo EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversal\nrate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Caspase

生化机理

EP1013 (F1013) 是一种广谱 Caspase 选择性抑制剂，用于研究 1 型糖尿病。

CAS号

223568-55-6

分子式

C18H23FN2O6

分子量

382.38 g/mol

PubChem编号

9907987

Isomeric SMILES

CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)CF)NC(=O)OCC1=CC=CC=C1

IIUPAC Name

(3S)-5-fluoro-3-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-4-oxopentanoic acid

INCHI

1S/C18H23FN2O6/c1-11(2)16(17(25)20-13(8-15(23)24)14(22)9-19)21-18(26)27-10-12-6-4-3-5-7-12/h3-7,11,13,16H,8-10H2,1-2H3,(H,20,25)(H,21,26)(H,23,24)/t13-,16-/m0/s1

InChi Key

LYBWGROBJJXCJJ-BBRMVZONSA-N

Smiles

CC(C)C(C(=O)NC(CC(=O)O)C(=O)CF)NC(=O)OCC1=CC=CC=C1

PubChem CID

9907987

MeSH Entry Terms

benzyloxycarbonyl-valyl-aspartic acid fluoromethyl ketone;EP1013;F573 compound;MX1013;N-benzyloxycabonyl-Val Asp-fluoromethyl ketone;Z-VD-FMK;zVD-FMK

溶解性

DMSO : 100 mg/mL (261.52 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

382.154 Da

单同位素质量Monoisotopic Mass

382.154 Da

拓扑极表面积Topological Polar Surface Area

122.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

534

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

1.8

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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