Enpp-1-IN-12

Enpp-1-IN-12

E648729-5mg

5mg

≥99%

2-8°C储存,避光,干燥

冰袋运输

Enpp-1-IN-12 (compound 43) is a potent and orally active ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activity In Vitro Enpp-1-IN-12 (5 μM) exhibits half-life and intrinsic clearance of >120 min and In Vivo Enpp-1-IN-12 (100 mg/kg; p.o.) inhibits tumor growth in LLC1 syngeneic murine tumor model for lung cancer . Enpp-1-IN-12 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (F=45.1%), half-life (t 1/2 =1.04 h), and C max (303.10 ng/mL) in healthy female BALB/c mice . Enpp-1-IN-12 (1 mg/kg; i.v.) exhibits half-life (t 1/2 =0.76 h), C max (308.64 ng/mL), and CL of 73.22 mL/min/kg in healthy female BALB/c mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 41 nM (ENPP1)

Enpp-1-IN-12（化合物 43）是一种强效口服活性外核苷酸焦磷酸酶/磷酸二酯酶 1（ENPP1）抑制剂，其 Ki 值为 41 nM。Enpp-1-IN-12 具有抗肿瘤活性。

2631703-41-6

C16H18N6O3S

374.42 g/mol

O=C(C(CC)SC1=NC(N)=NC2=C1NC=N2)NC3=CC=C(C(OC)=C3)O

DMSO : 50 mg/mL (133.54 mM; Need ultrasonic)