Enpp-1-IN-14

Enpp-1-IN-14

E649281-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

Enpp-1-IN-14 (Compound 015) is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC 50 value of 32.38 nM for recombinant human ENPP-1 . Enpp-1-IN-14 has anti-tumor activity In Vivo Enpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×10 5 MC38 cells) Dosage: 50 mg/kg Administration: IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site) Result: Significantly inhibited tumor growth. Form:Solid IC50& Target:IC 50 : 32.38 nM (recombinant human ENPP-1)

Enpp-1-IN-14（化合物 015）是一种强效的八核苷酸焦磷酸酶/磷酸二酯酶-1（ENPP1）抑制剂，对重组人 ENPP-1 的 IC 50 值为 32.38 nM。Enpp-1-IN-14 具有抗肿瘤活性。

2687222-59-7

C15H22ClN5O4S

403.88 g/mol

O=S(N)(N1CCN(CCC1)C2=C3C=C(OC)C(OC)=CC3=NC=N2)=O.Cl

DMSO : 9.62 mg/mL (23.82 mM; Need ultrasonic)