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名称

EMT inhibitor-1

别名

EMT抑制剂-1

英文名称

EMT inhibitor-1

货号

E649856-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

EMT inhibitor-1 is an inhibitor of of Hippo , TGF-β , and Wnt signaling pathways with antitumor activities. In Vitro EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex .C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Hippo, TGF-β, Wnt

生化机理

EMT 抑制剂-1 是一种具有抗肿瘤活性的 Hippo、TGF-β 和 Wnt 信号通路抑制剂。

CAS号

1638526-21-2

分子式

C12H12Cl2N2O2S

分子量

319.21 g/mol

PubChem编号

90718214

Isomeric SMILES

C1=CC(=C(C=C1C2=NSN=C2OCCCCO)Cl)Cl

IIUPAC Name

4-[[4-(3,4-dichlorophenyl)-1,2,5-thiadiazol-3-yl]oxy]butan-1-ol

INCHI

1S/C12H12Cl2N2O2S/c13-9-4-3-8(7-10(9)14)11-12(16-19-15-11)18-6-2-1-5-17/h3-4,7,17H,1-2,5-6H2

InChi Key

FWMUIOJZHOPPDX-UHFFFAOYSA-N

Smiles

C1=CC(=C(C=C1C2=NSN=C2OCCCCO)Cl)Cl

PubChem CID

90718214

溶解性

DMSO : ≥ 100 mg/mL (313.27 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

318 Da

单同位素质量Monoisotopic Mass

318 Da

拓扑极表面积Topological Polar Surface Area

83.500 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

276

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.6

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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