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Product details

名称

(Z)-4EGI-1

英文名称

(Z)-4EGI-1

货号

E650643-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation . (Z)-4EGI-1 effectively binds to eIF4E with an IC 50 of 43.5 μM and a K d value of 8.74 μM. (Z)-4EGI-1 has anticancer activity In Vitro (Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected. (Z)-4EGI-1 inhibits cancer cells proliferation with IC 50 values of 15.3 μM and 11.6 μM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: CRL-2813 melanoma cells Concentration: 15 µM, 30 µM Incubation Time: 6 hours Result: Markedly reduced the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin. Form:Solid IC50& Target:eIF4

生化机理

(Z)-4EGI-1是4EGI-1的Z-异构体，是eIF4E/eIF4G相互作用和翻译启动的抑制剂。(Z)-4EGI-1能有效地与eIF4E结合，其IC 50为43.5 μM，K d值为8.74 μM。(Z)-4EGI-1 具有抗癌活性。

CAS号

901787-88-0

分子式

C18H12Cl2N4O4S

分子量

451.28 g/mol

Smiles

O=C(O)/C(CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(C3=CC=C(Cl)C(Cl)=C3)=CS2

溶解性

DMSO : 50 mg/mL (110.80 mM; ultrasonic and warming and heat to 60°C)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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