EMT inhibitor-1

EMT抑制剂-1

EMT inhibitor-1

E656029-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

EMT inhibitor-1 is an inhibitor of of Hippo , TGF-β , and Wnt signaling pathways with antitumor activities. In Vitro EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex .C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Hippo, TGF-β, Wnt

EMT 抑制剂-1 是一种具有抗肿瘤活性的 Hippo、TGF-β 和 Wnt 信号通路抑制剂。

1638526-21-2(DMSO)

C12H12Cl2N2O2S

319.21 g/mol

C1=CC(=C(C=C1C2=NSN=C2OCCCCO)Cl)Cl