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名称

Epiberberine chloride

别名

氯化表小檗碱

英文名称

Epiberberine chloride

货号

E656451-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

干燥,-80℃储存

运输条件

超低温冰袋运输

产品介绍

Epiberberine chloride is an alkaloid isolated from Coptis chinensis , acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC 50 s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO - scavenging effect (IC 50 , 16.83 μM), and may protect against Alzheimer disease Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways Epiberberine has the potential effect in the research of diabetic disease In Vitro Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes, with an IC 50 of 52.8 μM. Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, and urinary output of KK-Ay mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:AChE BACE1 BChE

生化机理

氯化表小檗碱是从黄连中分离出来的一种生物碱，是一种强效的 AChE 和 BChE 抑制剂，也是一种非竞争性的 BACE1 抑制剂，其 IC 50 s 分别为 1.07、6.03 和 8.55 μM。表小檗碱氯化物具有抗氧化活性，可用于抗氧化剂和抗肿瘤药物。

CAS号

889665-86-5(DMSO)

分子式

C20H18ClNO4

分子量

336.363545 g/mol

Smiles

COC1=C(C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(C4=C3)OCO5)OC.[Cl-]

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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「No technical documents」

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「No related articles yet」

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