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Product details

名称

EG01377 dihydrochloride

别名

EG01377 二盐酸盐

英文名称

EG01377 dihydrochloride

货号

E661640-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

充氩,干燥,-80℃储存

运输条件

超低温冰袋运输

产品介绍

EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) , with a K d of 1.32 μM, and IC 50 s of 609 nM for both NRP1-a1 and NRP1-b1 . EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects IC50& Target:IC50: 609 nM (NRP1-a1 and NRP1-b) In Vitro:EG01377 (3-30 μM; 30 minutes) inhibits vascular endothelial growth factor A (VEGF-A) stimulated tyrosine phosphorylation of VEGF-R2/KDR. EG01377 (30 μM) is able to significantly reduce HUVEC cell migration in response to VEGFA. EG01377 (30 μM; 5 In Vivo:EG01377 (2mg/kg; i.v.) exhibits an encouraging half-life of 4.29 h, sufficient to sustain once per day dosing in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 week-old BABL/c Biological Activity:EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) , with a K d of 1.32 μM, and IC 50 s of 609 nM for both NRP1-a1 and NRP1-b1 . EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects

分子式

C26H32Cl2N6O6S2

分子量

659.6 g/mol

Smiles

O=S(C1=CC(C2=CC=C(CN)C=C2)=CC3=C1OCC3)(NC4=C(C(N[C@@H](CCC/N=C(N)/N)C(O)=O)=O)SC=C4)=O.Cl.Cl

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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