Elimusertib hydrochloride

RdRP-IN-2

E661718-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC 50 of 7 nM. Elimusertib hydrochloride has anti-tumor activity . Elimusertib hydrochloride can be used for the research of solid tumors and ly IC50& Target:ATR 7 nM (IC 50 ) In Vitro:Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a median IC 50 of 78 nM. Elimusertib hydrochloride potently suppresses hydroxyurea-induced H2AX phosphorylation (IC 50 : 36 nM) . Eli In Vivo:Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models. Elimusertib hydrochloride (50 mg/kg; p.o. Biological Activity:Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC 50 of 7 nM. Elimusertib hydrochloride has anti-tumor activity. Elimusertib hydrochloride can be used for the research of solid tumors and ly

C20H22ClN7O

411.89 g/mol

CN1N=CC=C1C2=C(C=CN=C3C4=CC=NN4)C3=NC(N5[C@H](C)COCC5)=C2.[H]Cl