肠激酶 人

E755277-50μg

50μg

重组

≥90%(SDS-PAGE&HPLC)

Human Enterokinase is expressed as a linear 1019 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of enterokinase, which consists of two polypeptide chains (heavy chain and light chain) held together by a single disulfide bond, resulting in formation of a biologically active heterodimer. The heavy chain consists of 784 amino acid residues, and the light consists of 235 amino acid residues. The mRNA is present in the proximal small intestine, and the protein is in enterocytes of the duodenum and proximal jejunum. The gene is mapped to human chromosome 21q21. Human Enterokinase is expressed as a linear 1019 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of enterokinase, which consists of two polypeptide chains (heavy chain and light chain) held together by a single disulfide bond, resulting in formation of a biologically active heterodimer. The heavy chain consists of 784 amino acid residues, and the light consists of 235 amino acid residues. The mRNA is present in the proximal small intestine, and the protein is in enterocytes of the duodenum and proximal jejunum. The gene is mapped to human chromosome 21q21.

蛋白酶（又称蛋白质分解酶、肽酶或蛋白酶）是一种水解蛋白质或肽中酰胺键的酶。大多数蛋白酶以特定的方式发挥作用，水解底物蛋白质或肽中特定残基或特定残基序列上或邻近的键。蛋白酶在大多数疾病和生物过程中都发挥着重要作用，包括产前和产后发育、繁殖、信号转导、免疫反应、各种自身免疫性和退行性疾病以及癌症。肠激酶按顺序裂解 D-D-D-D-K 的羧基。 它是一种丝氨酸蛋白酶，主要激活胰蛋白酶原。