- Harmful effect： 依酚氯铵的不良作用是由于乙酰胆碱结合毒蕈碱乙酰胆碱受体水平增加所致。更严重的不良作用是心律失常，特别是心动过缓、房室传导阻滞和心脏骤停。毒蕈碱胆碱能不良作用还包括支气管收缩，这是由于气道平滑肌收缩继发于毒蕈碱受体刺激增加。其他不良作用包括支气管分泌物、腹泻、唾液分泌、流泪、尿频尿急和瞳孔缩小。临床医生可以通过同时使用阿托品减轻大多数不良作用，阿托品作为毒蕈碱受体拮抗剂，可预防这些胆碱能不良作用的发生。
- Toxicity summary： 依酚氯铵过量会导致胆碱能危象，表现为乙酰胆碱过度结合毒蕈碱受体引起的毒蕈碱症状。胆碱能危象包括腹泻、尿频、瞳孔缩小、肌无力、支气管痉挛、心动过缓、呕吐和流泪。依酚氯铵过量的更严重后果涉及呼吸肌无力和心律失常，可能进展至致命结局。因此，临床医生必须确保气道和循环通畅。依酚氯铵过量的治疗是使用阿托品。阿托品是依酚氯铵的理想解毒剂，因为其起效时间与依酚氯铵相似。阿托品通过竞争性抑制由胆碱能神经节后神经支配的结构上的毒蕈碱受体发挥作用...
- Drug Induced Liver Injury： 参考: DOI:10.1016/j.drudis.2011.05.007
- Effects During Pregnancy and Lactation： ◉ 对哺乳和母乳的影响
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Research chemical CAS 116-38-1 10mM 1ml
Research chemical CAS 116-38-1 10mM 1ml, complete specifications, for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
