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Product introduction
EN6 是一种小分子体内自噬 (autophagy) 激活剂,其共价靶向溶酶体v-ATP 酶的 ATP6V1A 亚基中的半胱氨酸 277。EN6 介导的 ATP6V1A 修饰使 v-ATP 酶与 Rag 解偶联,导致 mTORC1 信号传导的抑制,溶酶体酸化增加和自噬激活。EN6 以溶酶体依赖性方式清除 TDP-43 聚集物,这是额颞叶痴呆的致病因子。 Information EN6 is a novel covalentautophagyactivator and targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase with an IC50 of 1.7 μM for recombinant human ATP6V1A protein.
Chinese name
EN6
English name
EN6
Chinese alias
-
English alias
BS-15697 | SCHEMBL21393135 | ZB1625 | EN300-1720461 | AC-36359 | Z1410267069 | AKOS037648810 | EN6 | EN-6 | ABM-4739 | 1808714-73-9 | C19H14F2N4O2 | HY-128892 | N-[4-fluoro-3-(prop-2-enamido)phenyl]-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide | 1-(2-fluo
CAS number
1808714-73-9
molecular formula
C19H14F2N4O2
molecular weight
368.34 g/mol
Exact mass
≥95%
PSA
76.000 Ų
Logp
3.07
Technical Documents
「No technical documents」
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EN6 98% 10mg

EN6 98% 10mg CAS 1808714-73-9, complete specifications for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:E910388-10mg
Product model:10mg
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Lead Time:30days
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