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Product introduction

ERD-308 是一个强效的、基于von Hippel-LindauE3配体的雌激素受体 (ER) 的PROTAC，有潜力用于 ER 阳性乳腺癌的研究。ERD-308 在5 nM 的浓度可诱导 95% 的 ER 降解(其在 MCF-7 和 T47D ER+ 细胞中测得的 DC50 (引起 50% 蛋白降解的有效浓度) 值分别为 0.17 nM 和 0.43 nM。 ERD-308 is a highly potent von Hippel-Lindau-based PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively).

Specs ⸢ View details ⸥

Chinese name

ERD-308, 雌激素受体-α拮抗剂

English name

ERD-308

Chinese alias

compound 32;ERD308

English alias

compound 32;ERD308

CAS number

2320561-35-9

molecular formula

C55H65N5O9S2

molecular weight

1004.26 g/mol

Exact mass

PSA

247.000 Å²

Logp

9.000

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ERD-308 ≥98% 10mg

Name: ERD-308 ≥98% 10mg
Brand: 麦克林
SKU: E933697-10mg

ERD-308 ≥98% 10mg CAS 2320561-35-9, complete specifications for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：E933697-10mg

Product model：10mg

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Lead Time：30days

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ERD-308 ≥98% 10mg

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