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Product details

名称

盐酸氟奋嗪, 多巴胺 D2 受体拮抗剂

分子类型

小分子

别名

氟非那嗪二盐酸盐 | 2-[4-[3-[2-(三氟甲基)-10H-吩噻嗪-10-基]丙基]哌嗪-1-基]乙醇 | 2-[4-[3-[2-(三氟甲基)吩噻嗪-10-基]丙基]哌嗪-1-基]乙醇二盐酸盐 | 盐酸氟奋乃静 | 氟奋乃静盐酸盐

英文别名

1-(2-Hydroxyethyl)-4-(3-(2-trifluoromethyl-10-phenothiazinylpropyl)piperazine dihydrochloride | 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-, dihydrochloride | CCRIS 4032 | 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-ph

英文名称

Fluphenazine hydrochloride

货号

F276205-1g

包装规格

浓度

≥95%

储存温度

-20°C储存,充氩

运输条件

超低温冰袋运输

产品介绍

Fluphenazine二盐酸盐是多巴胺受体D1/D2抑制剂。 Product description： Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor; used to deliver Fluphenazine to biological systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist.

生化机理

强力多巴胺D 2 / D 1受体拮抗剂（K i值为0.4（D 2），2.3（D 1），1.4（D 3），7.1（D 4）和25 nM（D 5））。抑制多巴胺诱导的腺苷酸环化酶活性增加（K i = 9 nM）。抗精神病药。在体内有活性。

来源

Synthetic

CAS号

146-56-5

分子式

C22H25F3N3OS.2HCl

分子量

510.44 g/mol

MDL号

MFCD00055212

PubChem编号

67356

Isomeric SMILES

C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl

IIUPAC Name

2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;dihydrochloride

INCHI

1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H

InChi Key

MBHNWCYEGXQEIT-UHFFFAOYSA-N

Smiles

C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl

PubChem CID

67356

PubChem SID

504754152

溶解性

Soluble in water to 100 mM

熔点

227 °C

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

509.128 Da

单同位素质量Monoisotopic Mass

509.128 Da

拓扑极表面积Topological Polar Surface Area

55.300 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

544.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Merck Index

4189

作用类型

拮抗剂

作用机制

多巴胺 D2 受体拮抗剂

备注

如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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