Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

FTI 276 TFA

别名

FTI 276 三氟乙酸

英文名称

FTI 276 TFA

货号

F647326-5mg

包装规格

5mg

浓度

≥98%

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC 50 s of 0.9 nM and 0.5 nM for Plasmodium falciparum and human, respectively Form:Solid IC50& Target:IC50: 0.9 nM (PFT, Plasmodium falciparum ), 0.5 nM (PFT, human)

生化机理

FTI-276 是一种蛋白法尼基转移酶（PFT）抑制剂，对恶性疟原虫和人类的 IC 50 s 分别为 0.9 nM 和 0.5 nM。

CAS号

1217471-51-6

分子式

C23H28F3N3O5S2

分子量

433.5911402 g/mol

PubChem编号

395753

Isomeric SMILES

CSCC[C@@H](C(=O)O)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2.C(=O)(C(F)(F)F)O

IIUPAC Name

(2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoic acid;2,2,2-trifluoroacetic acid

INCHI

1S/C21H27N3O3S2.C2HF3O2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14;3-2(4,5)1(6)7/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27);(H,6,7)/t15-,19+;/m1./s1

InChi Key

IAVHISGQCODLHL-WSCVZUBPSA-N

Smiles

CSCCC(C(=O)O)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2.C(=O)(C(F)(F)F)O

PubChem CID

395753

溶解性

DMSO : 100 mg/mL (182.61 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

547.142 Da

单同位素质量Monoisotopic Mass

547.142 Da

拓扑极表面积Topological Polar Surface Area

168.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

601.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！