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Product introduction

Fosmanogepix (APX001) 是一种广谱的抗侵袭性真菌感染药物。Fosmanogepix (APX001) 的靶标是真菌中糖基磷脂酰肌醇锚定甘露蛋白定位所需的保守 Gwt1 酶，这种抑制阻止了细胞壁甘露蛋白的适当定位，从而损害了细胞壁的完整性、生物膜的形成、胚管的形成和真菌的生长。可用于侵袭性真菌感染疾病的研究。 Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl prodrug which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections Form:Solid IC50& Target:Gwt1

Specs ⸢ View details ⸥

Chinese name

Fosmanogepix, GPI-anchored 壁转移蛋白 1 抑制剂

English name

Fosmanogepix

Chinese alias

福斯曼吉

English alias

(2-amino-3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-1-ium-1-yl)methyl hydrogen phosphate

CAS number

2091769-17-2

molecular formula

C22H21N4O6P

molecular weight

468.40 g/mol

Exact mass

PSA

148.000 Å²

Logp

1.6

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