Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

Flumexadol

分子类型

小分子

别名

氟美沙多

英文名称

Flumexadol

货号

F650514-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Flumexadol is a selective and affinity 5-HT 2C receptor agonist with a K i of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT 2A receptor. Flumexadol is an orally active non-narcotic analgesic In Vivo In rats and dogs dosed with 14 C-Flumexadol (CERM1841), the 14 C is excreted in the urine. The 14 C eliminated in the faeces of dog is significantly higher than for rat. Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species. Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances. The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid. In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate. The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Liquid IC50& Target:5-HT 2C Receptor 25 nM (Ki)

生化机理

氟美沙多是一种具有选择性和亲和力的 5-HT 2C 受体激动剂，其 (+)- 对映异构体的 K i 值为 25 nM，对 5-HT 2A 受体的选择性为 40 倍。氟美沙多是一种口服活性非麻醉性镇痛药。

CAS号

30914-89-7

分子式

C11H12F3NO

分子量

231.21 g/mol

PubChem编号

65774

Isomeric SMILES

C1COC(CN1)C2=CC(=CC=C2)C(F)(F)F

Smiles

C1COC(CN1)C2=CC(=CC=C2)C(F)(F)F

PubChem CID

65774

溶解性

DMSO : 33.33 mg/mL (144.15 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

231.087 Da

单同位素质量Monoisotopic Mass

231.087 Da

拓扑极表面积Topological Polar Surface Area

21.300 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

232

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！