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名称

三磷酸氟达拉滨三钠盐

英文别名

F-ara-ATP trisodium

英文名称

Fludarabine triphosphate trisodium

货号

F659287-5mg

包装规格

5mg

级别

Moligand™

浓度

≥95%

储存温度

避光,-20°C储存,充氩

运输条件

超低温冰袋运输

产品介绍

三磷酸氟达拉滨三钠盐是 Fludarabine (HY-B0069) 的活性代谢物，是一种有效的、非竞争性的、特异性的DNA引发酶 (DNA primase) 抑制剂，其 IC50 为 2.3 μM，Ki 为 6.1 μM。Fludarabine triphosphate trisodium 通过阻断 DNA 引发酶和引物 RNA 形成抑制 DNA 合成 (DNA synthesis)。Fludarabine triphosphate trisodium 可抑制核糖核苷酸还原酶和DNA聚合酶，最终导致细胞凋亡 (apoptosis)。 Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.

CAS号

74832-57-8(free base)

分子式

C10H12FN5Na3O13P3

分子量

591.12 g/mol

溶解性

H2O : 125 mg/mL (211.46 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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「No technical documents」

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