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Product details

名称

弗林蛋白酶人

货号

F755284-50U

包装规格

50U

浓度

≥2,000 unit/mL, buffered aqueous solution, recombinant, expressed in baculovirus infected Sf9 cells

产品介绍

弗林蛋白酶能够裂解多种蛋白质的前体，包括生长因子、血清蛋白（包括凝血和补体系统的蛋白酶）、基质金属蛋白酶、受体、病毒包膜糖蛋白和细菌外毒素，通常在共有序列 Arg-Xaa-(Lys/Arg)-Arg 标记的位点。 Furin is capable of cleaving precursors of a wide variety of proteins, including growth factors, serum proteins, including proteases of the blood-clotting and complement systems, matrix metalloproteinases, receptors, viral-envelope glycoproteins, and bacterial exotoxins, typically at sites marked by the consensus sequence Arg-Xaa-(Lys/Arg)-Arg.

生化机理

弗林蛋白酶是一种二元内切蛋白酶，定位于高尔基体。分子量为 52.7 kDa。在哺乳动物细胞的分泌和内吞途径中负责许多前体蛋白的蛋白水解成熟。 Furin 在其配对的碱性氨基酸加工位点切割前体蛋白。弗林蛋白酶的一些底物包括 von Willebrand 因子、转化生长因子 β 1 前体，前 β-分泌酶和前甲状旁腺激素。弗林蛋白酶是一种二元内切蛋白酶，定位于高尔基体。在哺乳动物细胞的分泌和内吞途径中负责许多前体蛋白的蛋白水解成熟。

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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